Upstream Bio, Inc. (UPB) Profit Margins

Over the twelve months to 2026-06-30, Upstream Bio, Inc. (UPB) had operating margin -5382.6%, net margin -4955.7%, free cash flow margin -4321.2%, according to EquiReason's reading of its SEC filings.

Source: SEC EDGAR filings · figures as of 2026-06-30 · read by EquiReason

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Biotechnology · Healthcare

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Market cap: 150.1M
P/E TTM: —
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Next earnings: 5 Nov, in 12 days

Line	FY2024 Dec 24	FY2025 Dec 25	TTM Jun 26
Operating margin	-3281.2%	-5618.8%	-5382.6%
Net margin	-2650.0%	-5026.0%	-4955.7%
FCF margin	-2518.3%	-4675.5%	-4321.2%

USD millions · SEC XBRL

Upstream Bio, Inc. — questions

What is Upstream Bio, Inc.'s operating margin?: -5382.6% over the twelve months to 2026-06-30.
What is Upstream Bio, Inc.'s net profit margin?: -4955.7% over the twelve months to 2026-06-30.

Every figure on this page comes from Upstream Bio, Inc.'s own SEC filings — see them on SEC EDGAR. Price data is licensed and shown only inside the product.

How these figures are read: methodology · EquiReason.

Important information. Figures on this page are taken from filings submitted to the U.S. Securities and Exchange Commission (SEC) and processed automatically by EquiReason. They may contain errors, omissions or delays, and EquiReason makes no representation or warranty as to their accuracy, completeness or timeliness. Always verify figures against the original filing on SEC EDGAR before relying on them.

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