Upstream Bio, Inc. (UPB) Financial Statements

Upstream Bio, Inc. (UPB) reported trailing twelve-month revenue of $3.2M (up 16.0% year on year) and net income of -$156.5M as of 2026-06-30, according to EquiReason's reading of its SEC filings. Free cash flow over the same period: -$136.5M.

Source: SEC EDGAR filings · figures as of 2026-06-30 · read by EquiReason

UPBUpstream Bio, Inc.Follow UPB — free

Biotechnology · Healthcare

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Market cap: 150.1M
P/E TTM: —
Dividend yield: —
52-week: —
Next earnings: 5 Nov, in 12 days

Fiscal-year columns end in the month shown. The current fiscal year appears once its annual report is filed; until then TTM = the last four reported quarters, to Jun 26.

Line	FY2024 Dec 24	FY2025 Dec 25	TTM Jun 26
Revenue	2.4	2.9	3.2
Research & development	63.0	136.8	145.8
Operating income	-77.8	-160.4	-170.0
Pre-tax income	-62.8	-143.4	-156.5
Income tax	0.0	0.0	0.0
Net income	-62.8	-143.4	-156.5
Diluted EPS ($)	-5.58	-2.66	-2.89
Diluted shares (mn)	13.7	53.9	—

USD millions · SEC XBRL

Upstream Bio, Inc. — questions

What is Upstream Bio, Inc.'s revenue?: $3.2M over the twelve months to 2026-06-30, up 16.0% year on year, from its 10-Q and 10-K filings.
What is Upstream Bio, Inc.'s net income?: -$156.5M over the twelve months to 2026-06-30.
What is Upstream Bio, Inc.'s free cash flow?: -$136.5M over the twelve months to 2026-06-30.
What are Upstream Bio, Inc.'s diluted earnings per share?: $-2.89 over the twelve months to 2026-06-30.

Every figure on this page comes from Upstream Bio, Inc.'s own SEC filings — see them on SEC EDGAR. Price data is licensed and shown only inside the product.

How these figures are read: methodology · EquiReason.

Important information. Figures on this page are taken from filings submitted to the U.S. Securities and Exchange Commission (SEC) and processed automatically by EquiReason. They may contain errors, omissions or delays, and EquiReason makes no representation or warranty as to their accuracy, completeness or timeliness. Always verify figures against the original filing on SEC EDGAR before relying on them.

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