Spyre Therapeutics, Inc. (SYRE) Institutional Ownership & Insider Trading

263 institutions reported holding Spyre Therapeutics, Inc. shares in 13F filings for the quarter ended 2026-06-30, according to EquiReason's reading of their SEC filings. 96 insider trades on Form 4 since 2025-10-01.

Source: SEC EDGAR filings · figures as of 2026-06-30 · read by EquiReason

SYRESpyre Therapeutics, Inc.Follow SYRE — free

Biotechnology · Healthcare

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Market cap: 8.0B
P/E TTM: —
Dividend yield: —
52-week: —
Next earnings: 5 Nov, in 12 days

Institutions · all 13F filers

quarter to 30 Jun 2026 · filers in both quarters

263 institutions held —% of the shares. Across filers that reported both quarters, shares held changed +15.3%.

Largest moves, shares (millions)

Institutional flow by quarter

net shares added or trimmed, millions · filers in both quarters

Quarter	Holders	Shares held, M	Change	Increased	New	Decreased	Closed
Jun 26	263	96	+15.3%	97	83	53	17
Mar 26	197	83	+3.5%	63	49	43	9
Dec 25	153	81	+26.4%	73	25	24	14
Sep 25	134	65	+1.5%	37	20	40	12
Jun 25	129	64	+2.5%	55	17	27	16
Mar 25	129	62	+4.5%	46	18	30	16
Dec 24	131	60	+16.1%	61	23	20	18
Sep 24	118	51	-0.3%	41	28	22	16

Spyre Therapeutics, Inc. — questions

Who owns Spyre Therapeutics, Inc. stock?: 263 institutions reported Spyre Therapeutics, Inc. shares in 13F filings for the quarter ended 2026-06-30. The largest: FMR LLC (14.8%), BlackRock, Inc. (7.4%), PERCEPTIVE ADVISORS LLC (4.9%).
Are Spyre Therapeutics, Inc. insiders buying or selling?: 96 insider trades on Form 4 since 2025-10-01; the full list, with dates, people and plan status, is on this page.

Every figure on this page comes from Spyre Therapeutics, Inc.'s own SEC filings — see them on SEC EDGAR. Price data is licensed and shown only inside the product.

How these figures are read: methodology · EquiReason.

Important information. Figures on this page are taken from filings submitted to the U.S. Securities and Exchange Commission (SEC) and processed automatically by EquiReason. They may contain errors, omissions or delays, and EquiReason makes no representation or warranty as to their accuracy, completeness or timeliness. Always verify figures against the original filing on SEC EDGAR before relying on them.

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