Septerna, Inc. (SEPN) Profit Margins

Over the twelve months to 2026-06-30, Septerna, Inc. (SEPN) had operating margin -44.0%, net margin -24.5%, free cash flow margin 106.3%, according to EquiReason's reading of its SEC filings.

Source: SEC EDGAR filings · figures as of 2026-06-30 · read by EquiReason

SEPNSepterna, Inc.Follow SEPN — free

Biotechnology · Healthcare

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Market cap: 1.9B
P/E TTM: —
Dividend yield: —
52-week: —
Next earnings: 9 Nov, in 16 days

Line	FY2024 Dec 24	FY2025 Dec 25	TTM Jun 26
Operating margin	-7518.4%	-148.6%	-44.0%
Net margin	-6678.9%	-106.4%	-24.5%
FCF margin	-6471.9%	238.7%	106.3%

USD millions · SEC XBRL

Septerna, Inc. — questions

What is Septerna, Inc.'s operating margin?: -44.0% over the twelve months to 2026-06-30.
What is Septerna, Inc.'s net profit margin?: -24.5% over the twelve months to 2026-06-30.

Every figure on this page comes from Septerna, Inc.'s own SEC filings — see them on SEC EDGAR. Price data is licensed and shown only inside the product.

How these figures are read: methodology · EquiReason.

Important information. Figures on this page are taken from filings submitted to the U.S. Securities and Exchange Commission (SEC) and processed automatically by EquiReason. They may contain errors, omissions or delays, and EquiReason makes no representation or warranty as to their accuracy, completeness or timeliness. Always verify figures against the original filing on SEC EDGAR before relying on them.

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