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Septerna, Inc. (SEPN) Institutional Ownership & Insider Trading

154 institutions reported holding Septerna, Inc. shares in 13F filings for the quarter ended 2026-06-30, according to EquiReason's reading of their SEC filings. 30 insider trades on Form 4 since 2025-10-01.

Source: SEC EDGAR filings · figures as of 2026-06-30 · read by EquiReason

SEPNSepterna, Inc.Follow SEPN — free
Biotechnology · Healthcare
—
Price chart with a free account
Market cap
1.9B
P/E TTM
—
Dividend yield
—
52-week
—
Next earnings
9 Nov, in 16 days

Institutions · all 13F filers

quarter to 30 Jun 2026 · filers in both quarters

154 institutions held —% of the shares. Across filers that reported both quarters, shares held changed +2.5%.

Increased+45New+44Decreased-28Closed-14

Largest moves, shares (millions)

Loomis Sayles & Co L P+0.6MAlgert Global+0.4MCatalio Capital Management+0.2MBvf Inc/il-1.4MVenrock Adviser-0.5MADAR1 Capital Management-0.1M

Institutional flow by quarter

net shares added or trimmed, millions · filers in both quarters
+0.0Dec 24+1.2Mar 25-0.8Jun 25+0.1Sep 25+0.8Dec 25+0.3Mar 26+1.1Jun 26
QuarterHoldersShares held, MChangeIncreasedNewDecreasedClosed
Jun 2615447+2.5%45442814
Mar 2612446+0.7%38223022
Dec 2512246+1.8%2840265
Sep 258245+0.3%30101616
Jun 258944-1.8%3125195
Mar 257145+2.6%23191219
Dec 247044—————

Septerna, Inc. — questions

Who owns Septerna, Inc. stock?
154 institutions reported Septerna, Inc. shares in 13F filings for the quarter ended 2026-06-30. The largest: RA CAPITAL MANAGEMENT, L.P. (15.0%), TRV GP V, LLC (13.3%), Driehaus Capital Management LLC (9.5%).
Are Septerna, Inc. insiders buying or selling?
30 insider trades on Form 4 since 2025-10-01; the full list, with dates, people and plan status, is on this page.

Every figure on this page comes from Septerna, Inc.'s own SEC filings — see them on SEC EDGAR. Price data is licensed and shown only inside the product.

How these figures are read: methodology · EquiReason.